NCT07654647 Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.
| NCT ID | NCT07654647 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Latakia University |
| Condition | Hemifacial Microsomia |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2026-04-26 |
| Primary Completion | 2026-11-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2026-04-26 with a primary completion date of 2026-11-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This clinical study aims to evaluate the effectiveness of patient-specific 3D-printed titanium facial implants in the reconstruction and aesthetic correction of facial defects. The study will include patients presenting with congenital, traumatic, or post-surgical facial deformities requiring reconstructive intervention. Eligible participants will undergo preoperative clinical assessment and radiological imaging to design customized implants using computer-aided design (CAD) and 3D printing technology. The implants will be fabricated from medical-grade titanium and surgically placed according to standardized maxillofacial reconstructive protocols. Postoperative follow-up will assess functional outcomes, implant stability, complication rates, and aesthetic improvement over a defined observation period. Outcome evaluation will include clinical examination and patient-reported satisfaction measures. The objective of this study is to determine whether patient-specific 3D-printed titanium implants provide reliable functional restoration and improved aesthetic outcomes in facial reconstruction compared to conventional reconstructive techniques.
Eligibility Criteria
Inclusion Criteria: * Age 18 years or older. * Presence of facial bone defects resulting from cystic or tumoral osteolytic lesions. * Acquired or congenital facial deformities associated with bony defects or facial asymmetry. * Patients requiring patient-specific 3D-printed titanium implants for maxillofacial reconstruction. * Aesthetic indications requiring custom facial implant design, including microgenia (chin retrusion). * Ability to provide written informed consent. Exclusion Criteria: * Active pathological lesions at the time of enrollment. * Age below 18 years. * History of radiotherapy within 12 months prior to enrollment. * Chronic untreated vitamin D deficiency. * Uncontrolled diabetes mellitus. * Inability or unwillingness to comply with follow-up requirements.
Contact & Investigator
Basim A Slim
STUDY CHAIR
Latakia University
Frequently Asked Questions
Who can join the NCT07654647 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Hemifacial Microsomia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07654647 currently recruiting?
Yes, NCT07654647 is actively recruiting participants. Contact the research team at ahmad.fayez.ahmad@latakia-univ.edu.sy for enrollment information.
Where is the NCT07654647 trial being conducted?
This trial is being conducted at Latakia, Syria.
Who is sponsoring the NCT07654647 clinical trial?
NCT07654647 is sponsored by Latakia University. The principal investigator is Basim A Slim at Latakia University. The trial plans to enroll 30 participants.