NCT07410156 Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods.
| NCT ID | NCT07410156 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fayoum University |
| Condition | Gingival Pigmentation |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2026-07-01 |
| Primary Completion | 2027-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2026-07-01 with a primary completion date of 2027-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The present study will be carried to evaluate the efficacy of MN technique with topical Silymarin application in treating gingival hyperpigmentation in comparison with Laser and scalpel methods. This evaluation will be done clinically. The questions to be answered: * Is there a statistical difference between the microneedling (MN) technique with topical silymarin application, the scalpel technique, and the diode laser in providing clinical and aesthetic advantages in the treatment of gingival pigmentation? * What medical problems do participants have when using of Silymarin topically? Participants will be: Group 1 : The gingiva of the facial surfaces of the selected area will be de-epithelized by conventional method through blades no 15c. Group 2 : The gingiva of the facial surfaces of the selected area will be de-epithelized by A Diode laser Device (serolaser). Group 3 : The gingiva of the facial surfaces of the selected area will be treated by repetitive punctures with Dr.Pen ULTIMA - A6 needle tip. Silymarin is applied topically for ten minutes.
Eligibility Criteria
Inclusion Criteria: 1. Patients will be free from any systemic diseases according to criteria of Modified Cornell Medical Index 2. Patient with physiologic pigmentation 3. Non smoker 4. Patient agree to sign the written consent 5. Both genders Exclusion Criteria: 1. Pregnant and lactating women 2. Systemic conditions affect melanin production 3. Medications induce pigmentation or enlargement 4. Those with known allergies to silymarin.
Contact & Investigator
Nayroz Mohammed Tarrad, Professor
PRINCIPAL INVESTIGATOR
Oral Medicine and Periodontology Faculty of Dentistry, Fayoum University
Frequently Asked Questions
Who can join the NCT07410156 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Gingival Pigmentation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07410156 currently recruiting?
Yes, NCT07410156 is actively recruiting participants. Contact the research team at tt1139@fayoum.edu.eg for enrollment information.
Where is the NCT07410156 trial being conducted?
This trial is being conducted at Al Fayyum, Egypt.
Who is sponsoring the NCT07410156 clinical trial?
NCT07410156 is sponsored by Fayoum University. The principal investigator is Nayroz Mohammed Tarrad, Professor at Oral Medicine and Periodontology Faculty of Dentistry, Fayoum University. The trial plans to enroll 30 participants.