CHronic Nonbacterial Osteomyelitis International Registry
Trial Parameters
Brief Summary
The objective of the study is to establish a prospective disease registry for chronic recurrent multifocal osteomyelitis (CRMO)/chronic nonbacterial osteomyelitis (CNO) in order to investigate the natural history of the disease and the responses of patients to different clinical managements over 10 years.
Eligibility Criteria
Inclusion Criteria: * \- Age at enrollment is equal to or younger than 21 years of age * Presence of bone edema on STIR or T2 fat saturation sequence on MRI within 12 weeks of enrollment * Whole body imaging evaluation (either WB MRI or bone scintigraphy) * Bone biopsy to exclude infection or malignancy unless bone lesions follow typical distribution or there is IBD, psoriasis, or palmar plantar pustulosis Exclusion Criteria: * \- History of or current malignancy * Current infectious osteomyelitis * Contraindication to the selected treatment agent