Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response
Trial Parameters
Brief Summary
This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.
Eligibility Criteria
Inclusion Criteria: INCLUSION CRITERIA for CANNABIS USING patient: Subjects will be eligible if they meet ALL of the following criteria: 1. Daily or near daily cannabis use (inhaled via joint/cigarette or pipe) equivalent to AT LEAST 20 "joint years" (number of joints/cigarettes per day multiplied by number of years during which cannabis was smoked) by self-report and validated through urine drug screen. 2. Never or limited exposure to inhaled tobacco products (equivalent to LESS THAN one "pack year" in a lifetime) by selfreport and validated through negative urine cotinine screen. 3. Capacity to answer screening questions and provide informed consent at time of interview, along with contact information INCLUSION CRITERIA for CONTROL patient: Subjects will be eligible if they meet all of the following: 1. No cannabis use ever by self-report, and validated through urine drug screen. 2. Never users of tobacco/cigarettes 3. Capacity to answer screening questions and provide informed conse