NCT07048028 Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
| NCT ID | NCT07048028 |
| Status | Recruiting |
| Phase | — |
| Sponsor | ESRA DAĞCI |
| Condition | Apical Periodontitis |
| Study Type | INTERVENTIONAL |
| Enrollment | 90 participants |
| Start Date | 2025-05-05 |
| Primary Completion | 2025-11-17 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 90 participants in total. It began in 2025-05-05 with a primary completion date of 2025-11-17.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment. The main questions it will answer are: How much does a chitosan solution used alone lower the number of bacteria inside the root canal? Do the combinations sodium hypochlorite + chitosan or sodium hypochlorite + EDTA lower bacteria even more than chitosan alone? Researchers will compare the three irrigation methods to see which one achieves the greatest bacterial reduction. What participants will do Be randomly assigned to one of three groups: Group 1: Chitosan only Group 2: Sodium hypochlorite followed by chitosan Group 3: Sodium hypochlorite followed by EDTA Attend two clinic visits: Visit 1: Receive standard root-canal treatment under local anesthesia. Provide tiny paper-point samples from inside the canal before and after the assigned rinse (painless; takes seconds). Visit 2 (about 1 week later): Return for a check-up and final filling of the tooth. Record any pain or discomfort for the first three days after treatment in a simple diary (or by phone). About 90 adults will take part. All procedures are routine in dental care, and there is no cost to participate. Participants may withdraw at any time and can ask the study dentist any questions throughout the trial.
Eligibility Criteria
Inclusion Criteria: * Patients who agreed to participate in the study * Systemically healthy patient * Mandibular premolar teeth * Teeth that respond negatively to thermal tests and EPT * Patients who have not used antibiotics for at least 2 weeks Exclusion Criteria: * Teeth with previous primary root-canal treatment * Pregnant patients * Severely curved roots (\>25° curvature) * Canals with instrument separation during preparation * Calcified (obliterated) canals
Contact & Investigator
Fatih Cakici, DDS, PhD
PRINCIPAL INVESTIGATOR
Ordu University Faculty of Dentistry
Frequently Asked Questions
Who can join the NCT07048028 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Apical Periodontitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07048028 currently recruiting?
Yes, NCT07048028 is actively recruiting participants. Contact the research team at dagci.esra.496@gmail.com for enrollment information.
Where is the NCT07048028 trial being conducted?
This trial is being conducted at Ordu, Turkey (Türkiye).
Who is sponsoring the NCT07048028 clinical trial?
NCT07048028 is sponsored by ESRA DAĞCI. The principal investigator is Fatih Cakici, DDS, PhD at Ordu University Faculty of Dentistry. The trial plans to enroll 90 participants.