NCT07463391 Chinese Classics Recitation Training in Subjective Cognitive Decline
| NCT ID | NCT07463391 |
| Status | Recruiting |
| Phase | — |
| Sponsor | China Medical University Hospital |
| Condition | Subjective Cognitive Decline (SCD) |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-08-01 |
| Primary Completion | 2029-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2026-08-01 with a primary completion date of 2029-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Subjective cognitive decline (SCD) is considered a preclinical condition associated with an increased risk of dementia and Alzheimer's disease. Effective early behavioral interventions remain limited, and the neurobiological mechanisms underlying cognitive training effects are not fully understood, particularly in culturally specific educational contexts. This randomized, assessor-blinded, controlled clinical trial will enroll 60 individuals with SCD to evaluate the effects of a six-month structured Chinese Classics recitation training program. Participants will be randomly assigned to either an intervention group or a non-active control group. Assessments will be conducted at baseline, immediately post-intervention, and during annual follow-up. Multimodal evaluations will include neuropsychological testing, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), blood biomarker profiling, gut microbiota analysis, and fecal metabolomics. The study aims to examine clinical outcomes and explore potential neurobiological and systemic correlates associated with culturally adapted cognitive training.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 60 years old * At least two "yes" responses to the following questions are required: 1. Forgetting where things are placed? 2. Unable to recall the names of good friends? 3. Unable to follow and recall conversation? 4. Subjective memory problems? 5. Consider own memory to be worse than others of a similar age? Exclusion Criteria: * Objective cognitive impairment defined as ≥ 1.5 standard deviations below standardized cognitive testing (e.g., MMSE) * Diagnosis of MCI * Clinical Dementia Rating (CDR) ≥ 0.5 * Diagnosis of major depressive disorder * Beck Anxiety Inventory score ≥ 16 * Other medical or neurological conditions that could explain cognitive decline (e.g., vascular dementia, traumatic brain injury) * Claustrophobia * Contraindications of MRI (e.g., non-MRI-compatible cardiac pacemaker or devices implanted within the past three months)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07463391 clinical trial?
This trial is open to participants of all sexes, aged 60 Years or older, studying Subjective Cognitive Decline (SCD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07463391 currently recruiting?
Yes, NCT07463391 is actively recruiting participants. Contact the research team at tshengdar@gmail.com for enrollment information.
Where is the NCT07463391 trial being conducted?
This trial is being conducted at Taichung, Taiwan.
Who is sponsoring the NCT07463391 clinical trial?
NCT07463391 is sponsored by China Medical University Hospital. The trial plans to enroll 60 participants.