| NCT ID | NCT07338006 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Health Sciences Lahore |
| Condition | Chest Wall Tumor |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2021-01-01 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2021-01-01 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Chest wall reconstruction following tumor or infection-related resections remains a challenging aspect of thoracic surgery, requiring restoration of structural stability and preservation of respiratory mechanics. While polymethyl methacrylate (PMMA) bone cement has long been used for rigid reconstruction, its limitations-including high cost, rigidity, infection risk, and interference with normal respiratory motion-pose challenges in resource-constrained settings. Twisted stainless steel wires offer a low-cost, flexible alternative that allows dynamic chest wall movement and easier adaptability in low- and middle-income countries such as Pakistan. To compare postoperative outcomes, complications, and cost-effectiveness of chest wall reconstruction using twisted stainless steel wires versus PMMA bone cement over a two-year period (January 2025 - December 2026). This prospective cohort study was conducted in the Department of Thoracic Surgery, Services Hospital, Lahore, a high-volume tertiary care and referral center. Patients undergoing chest wall reconstruction following resection for tumors, infections, or trauma were enrolled and divided into two groups based on the reconstruction technique used: Group A (twisted steel wires) and Group B (PMMA bone cement). Parameters assessed included postoperative pain (VAS scores), respiratory function, chest wall stability, complications (infection, wound dehiscence, prosthesis exposure), duration of hospital stay, readmission rate, and cost of reconstruction. Data were analyzed to compare clinical and functional outcomes between both cohorts.
Eligibility Criteria
Inclusion Criteria: * Patients aged ≥18 years undergoing partial or full-thickness chest wall resection. * Defects requiring rigid or semi-rigid reconstruction involving two or more ribs or the sternum. Exclusion Criteria: * Patients with small defects managed by primary closure or soft tissue-only reconstruction. * Patients with concurrent major intrathoracic resections (e.g., pneumonectomy) may confound postoperative respiratory assessment. * Recurrent disease requiring revision reconstruction. * Patients unwilling or unable to provide consent or comply with follow-up.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07338006 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Chest Wall Tumor. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07338006 currently recruiting?
Yes, NCT07338006 is actively recruiting participants. Contact the research team at zeeshan.sarwar195@gmail.com for enrollment information.
Where is the NCT07338006 trial being conducted?
This trial is being conducted at Lahore, Pakistan.
Who is sponsoring the NCT07338006 clinical trial?
NCT07338006 is sponsored by University of Health Sciences Lahore. The trial plans to enroll 50 participants.