NCT05380622 CHART Study of Coronary CT Angiography in Coronary Artery Disease
| NCT ID | NCT05380622 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Shanghai Zhongshan Hospital |
| Condition | Coronary Artery Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 5,000 participants |
| Start Date | 2015-01-01 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 5,000 participants in total. It began in 2015-01-01 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
In a cohort of patients referred to coronary computed tomography angiography (CCTA), the investigators aim: 1. To describe the natural history of the coronary atherosclerotic plaque development and progression or regression, as well as the plaque characterization and phenotypes over time by CCTA among deferred coronary lesions 2. To explore the precursors of plaques leading to acute coronary syndrome (ACS) or chronic coronary syndrome (CCS) in deferred coronary lesions 3. To investigate prognostic implication of qualitative and quantitative plaque analysis of stenosis and plaque features, disease patterns, hemodynamic parameters, and fat metrics on CCTA along with physiologic assessment 4. To investigate the effects of different treatment strategies according to stenosis and plaque features, fat metrics on CCTA along with physiologic assessments.
Eligibility Criteria
Inclusion Criteria: * Patients with an indication for CCTA. * Qualified patients who have signed a written informed consent form. Exclusion Criteria: * Left ventricular ejection fraction \< 35% * Acute ST-elevation myocardial infarction within 72 hours or previous coronary artery bypass graft surgery * Abnormal epicardial coronary flow (TIMI flow \< 3) * Planned coronary artery bypass graft surgery after diagnostic angiography * Poor quality of CCTA or other reasons by core lab that are unsuitable for plaque, physiological or fat analysis * Patients with a stent in the target vessel
Contact & Investigator
Junbo Ge, Professor
STUDY CHAIR
Fudan University
Frequently Asked Questions
Who can join the NCT05380622 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Coronary Artery Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05380622 currently recruiting?
Yes, NCT05380622 is actively recruiting participants. Contact the research team at niceday1987@hotmail.com for enrollment information.
Where is the NCT05380622 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT05380622 clinical trial?
NCT05380622 is sponsored by Shanghai Zhongshan Hospital. The principal investigator is Junbo Ge, Professor at Fudan University. The trial plans to enroll 5,000 participants.