NCT02434393 Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
| NCT ID | NCT02434393 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Southern California |
| Condition | Major Depression |
| Study Type | OBSERVATIONAL |
| Enrollment | 120 participants |
| Start Date | 2015-03-04 |
| Primary Completion | 2027-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 120 participants in total. It began in 2015-03-04 with a primary completion date of 2027-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of new participants for a period of 30 months. Data from an additional 300 non-depressed subjects will be used from ADNI studies for comparison. Depression history, symptom severity and health information will be collected at the initial visit to determine eligibility. An magnetic resonance imaging (MRI) scan, as well as amyloid (florbetapir) and tau (flortaucipr) positron emission tomography (PET) imaging will be conducted at San Francisco VA. Collection of plasma and serum for biomarkers, clinical assessments and cognitive assessments will be conducted at two time points. Blood samples will also be collected for genetic analysis.
Eligibility Criteria
Inclusion Criteria: 1\. Individual participated in original Characterizing Cognitive Decline in Late Life Depression study or Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression Study. Exclusion Exceptions: 1. Antidepressant medication treatment is allowed only if the medication dose is stable for 4 weeks prior to the MRI scan. 2. Psychotherapy interventions is allowed only if they have completed at least 4 weeks of individual or group psychotherapy intervention prior to the MRI scan. 3. Participants taking cognitive enhancing medications will be able to enter the study.
Contact & Investigator
Scott Mackin, PhD
STUDY DIRECTOR
University of California, San Francisco
Frequently Asked Questions
Who can join the NCT02434393 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, studying Major Depression. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT02434393 currently recruiting?
Yes, NCT02434393 is actively recruiting participants. Contact the research team at nithya.ganesh@ucsf.edu for enrollment information.
Where is the NCT02434393 trial being conducted?
This trial is being conducted at San Francisco, United States, Pittsburgh, United States.
Who is sponsoring the NCT02434393 clinical trial?
NCT02434393 is sponsored by University of Southern California. The principal investigator is Scott Mackin, PhD at University of California, San Francisco. The trial plans to enroll 120 participants.
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