Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
Trial Parameters
Brief Summary
Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
Eligibility Criteria
Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for all study visits 3. Aged 18 years and older 4. In good health based on self-reported medical conditions via an online survey Exclusion Criteria: 1. Known allergic reactions to components of the study vaccine 2. Known latex allergy 3. History of severe reactions following previous immunization with licensed or unlicensed influenza virus vaccines 4. History of GBS within 6 weeks of receipt of a previous influenza vaccine 5. Immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months 6. Treatment with immunoglobulin or another blood product within the 3 months prior to enrollment in this study 7. Active neoplastic disease (excluding non-melanoma skin cancer or prostate cancer that is stable in the absen