Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients
This research study collects bile samples, bile duct brushings, and medical information from people with Primary Sclerosing Cholangitis (PSC) and healthy controls. Researchers will use these samples to grow and study bile duct cells in the laboratory to better understand what changes occur in the liver with PSC. This basic research may help scientists develop better treatments for PSC in the future.
Key Objective: This study aims to improve understanding of how liver cells change in PSC, which could lead to new diagnostic tools and treatments for the disease.
Who to Consider: People with PSC or healthy individuals willing to provide bile samples and medical information to support research into understanding this liver disease should consider participating.
Trial Parameters
Brief Summary
The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.
Eligibility Criteria
Inclusion Criteria: PSC * Patients diagnosed with PSC between the age of 18 and 85. * The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings and compatible liver biopsies if available. * Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation. Patients with PSC and Cholangiocarcinoma will be included. Controls • Controls without history of PSC or evidence of other chronic liver disease of either gender that will participate in this study should be between the ages of 18-85. Exclusion Criteria: * Patients unable to provide inform consent. * Prisoners and institutionalized individuals. * PSC with orthotopic liver transplantation * History of Roux En Y procedure