NCT06613256 Characterisation of Endothelial Cells in Different Inflammatory Pathologies
| NCT ID | NCT06613256 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Royal Surrey County Hospital NHS Foundation Trust |
| Condition | Sepsis |
| Study Type | OBSERVATIONAL |
| Enrollment | 105 participants |
| Start Date | 2024-07-16 |
| Primary Completion | 2026-07-17 |
Trial Parameters
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Brief Summary
The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery. The main question we plan to answer is: 'What molecular pathways are differentially expressed during inflammatory pathologies?'
Eligibility Criteria
Inclusion Criteria: Healthy volunteer * Adult ≥ 18 years * Able and willing to give consent Surgical patients * Adult ≥ 18 years * Patients admitted to RSFT for planned major surgery Critically ill patients * Adult ≥ 18 years * Emergency admission to ICU at RSFT * Meets the sepsis 3.0 definition Exclusion Criteria: Healthy volunteer * Not currently a patient within the hospital * Absence of inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes, cardiovascular disease and CKD. * Not on immunomodulatory medications, such as corticosteroids * History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation) Surgical patients * Patients with restricted liberty, prisoners or under legal protection * Anticipated prohibitively difficult venous cannulation * Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculit