Trial Parameters
Brief Summary
The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Small Vessel Disease (CSVD) and in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CSVD, , to find independent imaging markers, and to optimize clinical management.
Eligibility Criteria
Inclusion Criteria: 1. Sign informed consent. 2. Age\>18 3. At least one of the following CSVD MRI characteristics: ①recent small subcortical infarct;②lacune of presumed vascular origin;③white matter hypertensity of presumed vascular origin;④perivascular space;⑤cerebral microbleeds;⑥brain atrophy Exclusion Criteria: 1. Unable to cooperate with inspectors 2. Non-vascular white matter lesions 3. Other cognitive diseases (such as alzheimer's disease, Parkinson's disease or thyroid disease) 4. Serious systemic illness, such as heart, liver, kidney disease or major mental illness 5. Contraindications for imaging examination