NCT07276490 Central Haemodynamics and Pacing for AV Block
| NCT ID | NCT07276490 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Tartu |
| Condition | Atrioventricular Block |
| Study Type | INTERVENTIONAL |
| Enrollment | 124 participants |
| Start Date | 2025-11-28 |
| Primary Completion | 2027-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 124 participants in total. It began in 2025-11-28 with a primary completion date of 2027-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.
Eligibility Criteria
Inclusion Criteria: * Age 18-80 years * Diagnosis of atrioventricular block * Expected survival \>1 year Exclusion Criteria: * Reduced left ventricular ejection fraction (EF \<45%) * Expected ventricular pacing burden \<20% * Inter-arm systolic blood pressure difference \>15 mmHg * Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days * Secondary hypertension * Orthostatic hypotension * Clinically significant valvular heart disease * Congenital heart disease * Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed * Pregnancy or breastfeeding * Withdrawal of consent by the subject * Loss of contact during the study
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07276490 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Atrioventricular Block. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07276490 currently recruiting?
Yes, NCT07276490 is actively recruiting participants. Contact the research team at silver.heinsar@ut.ee for enrollment information.
Where is the NCT07276490 trial being conducted?
This trial is being conducted at Tallinn, Estonia, Tartu, Estonia.
Who is sponsoring the NCT07276490 clinical trial?
NCT07276490 is sponsored by University of Tartu. The trial plans to enroll 124 participants.