Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer
Trial Parameters
Brief Summary
This phase I trial studies how well cemiplimab before and after surgery works in treating patients with high risk cutaneous squamous cell cancer. Immunotherapy with monoclonal antibodies, such as cemiplimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cemiplimab before surgery may improve risk of the cancer returning in patients with high risk cutaneous squamous cell cancer.
Eligibility Criteria
Inclusion Criteria: * Patient must have a known diagnosis of high risk cSCC defined by the following criteria: * Nodal disease with extracapsular extension (ECE) and at least one node \>= 20 mm on the surgical pathology report * In-transit metastases (ITM) defined as skin or subcutaneous metastases that are \> 2 cm from the primary lesion but are not beyond the regional nodal basin * T4 lesion for head and neck CSCC * Perineural invasion (PNI), defined as clinical and/or radiologic involvement of named nerves * Recurrent CSCC, defined as CSCC that arises within the area of the previously resected tumor, or at least one of the following additional features: * \>= N2b disease associated with the recurrent lesion * Nominal \>= T3 (recurrent lesion \>= 4 cm in diameter or minor bone erosion or deep invasion \> 6 mm measured from the granular layer of normal adjacent epithelium) * Poorly differentiated histology and \>= 20 mm diameter of recurrent lesion. The recurrent lesion must be docume