NCT04018729 Cell Therapy Associated With Endobronchial Valve
| NCT ID | NCT04018729 |
| Status | Recruiting |
| Phase | Phase 2, Phase 3 |
| Sponsor | Hospital de Clinicas de Porto Alegre |
| Condition | Chronic Obstructive Pulmonary Disease Severe |
| Study Type | INTERVENTIONAL |
| Enrollment | 34 participants |
| Start Date | 2019-11-19 |
| Primary Completion | 2020-08-17 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 34 participants in total. It began in 2019-11-19 with a primary completion date of 2020-08-17.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases worldwide and is considered a public health problem. The World Health Organization estimates that about 210 million people have COPD. Disease-related mortality is more than 3 million, representing 5% of all deaths, 90% of this mortality being concentrated in middle- and low-income countries. COPD can be subdivided into chronic bronchitis and emphysema. Emphysema, the focus of this project, is histologically defined by the permanent increase of the distal air spaces to the terminal bronchioles associated with the destruction of the alveolar septa in the lung. Approximately two-thirds of adult men and a quarter of women (most without dysfunction) will have well-defined emphysema, but often of limited extent. Mesenchymal stem cells (MSCs) have anti-inflammatory, anti-fibrotic, microbicide and repair potential. Regarding COPD, several authors have concentrated efforts in the investigation of the relationship between the severity of the condition and the various sources of adult stem cells. Apparently the lungs have a high chemotactic effect in relation to adult stem cells, since several studies have evidenced a high implantation (6-20%) of stem cells derived from bone marrow, administered systemically, in the pulmonary tissue of receptors. Therefore, MSCs has been tested in different lung diseases have no effective treatment, such as pulmonary fibrosis, acute respiratory distress syndrome, asthma, COPD positive results, such as reduction of fibrosis, reduction of proliferation inflammatory cells and cytokines, reduction of infectious processes and recovery of the histological changes caused by pulmonary emphysema. Based on these findings, the purpose of this project is to evaluate the safety and efficacy of endoscopic administration of bone marrow stem cells in patients with severe homogeneous emphysema and evaluating the feasibility, efficacy and safety of this procedure.
Eligibility Criteria
Inclusion Criteria: * Diagnosis of severe heterogeneous pulmonary emphysema (at least 10% of total lung parenchyma or 25% of target lobe with density \< -950HU); * Heterogeneity\> 15pp (difference of at least 15 percentage points of lung parenchyma with density greater than -950HU between the treated lobe(s) and the remaining lung on the same side) * Estimates of low or non-existent collateral ventilation (fissure integrity\> 95% measured by VIDA Diagnostics or collateral ventilation measured by negative Chartis® System) * Total lung capacity\> 100% of predicted * Residual volume\> 175% of predicted * FEV1 \<50% of predicted post-bronchodilator * DLCO (diffusing capacity of the lungs for carbon monoxide) \<45% of predicted post-bronchodilator * Body Mass Index (BMI) Greater than 18Kg/m2 and less than 35Kg/m2. * Optimized clinical treatment * Daily physical activities limitation * Possibility of pulmonary rehabilitation * Preserved ventricular function (LVEF\> 40%) * Cessation of smoking ≥ 4 months * Dyspnea MMRC ≥ 2 Exclusion Criteria: * Homogeneous emphysema * Estimated collateral ventilation observed on CT scanned by VIDA vision software (VIDA vision®, VIDA Diagnostics, Iowa-USA) - Fissure integrity on target lobe less than 75%. * Use of continuous systemic corticosteroid therapy\> 20mg QD (quaque die, once a day) of prednisone (or equivalent) * Active lung or extra pulmonary infection * Coronary heart disease and/or severe ventricular dysfunction * Significant renal or hepatic disease * Immunosuppressive disease * Rheumatologic or orthopedic disease limiting physical capacity; * Cognitive inability to understand study procedures; * Impression by clinical research investigators with a lifespan of less than a year1; * Active smoking * Malignant neoplasia with estimated prognosis of survival \<2 years * Psychosocial problems * Pregnancy
Contact & Investigator
Hugo G Oliveira, PhD
PRINCIPAL INVESTIGATOR
Hospital de Clinicas de Porto Alegre
Frequently Asked Questions
Who can join the NCT04018729 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Chronic Obstructive Pulmonary Disease Severe. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT04018729 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT04018729 currently recruiting?
Yes, NCT04018729 is actively recruiting participants. Contact the research team at hugo@hugooliveira.org for enrollment information.
Where is the NCT04018729 trial being conducted?
This trial is being conducted at Porto Alegre, Brazil.
Who is sponsoring the NCT04018729 clinical trial?
NCT04018729 is sponsored by Hospital de Clinicas de Porto Alegre. The principal investigator is Hugo G Oliveira, PhD at Hospital de Clinicas de Porto Alegre. The trial plans to enroll 34 participants.