NCT07037017 CBT Effects on Neural, Physiological, and Attentional Responses in Anorexia Nervosa
| NCT ID | NCT07037017 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Istanbul Nisantasi University |
| Condition | Eating Disorders (Excluding Anorexia Nervosa) |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-05-15 |
| Primary Completion | 2025-09-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-05-15 with a primary completion date of 2025-09-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized controlled trial investigates the neurophysiological, physiological, and attentional effects of Cognitive-Behavioral Therapy (CBT) in individuals with restrictive-type anorexia nervosa (AN). The study compares two groups: one receiving a 12-week CBT intervention, and one placed on a waitlist (no active treatment during the study period). All participants undergo pre- and post-intervention assessments using electroencephalography (EEG), galvanic skin response (GSR), and eye-tracking while exposed to visual stimuli related to food, body image, and self-appearance. The primary outcomes include neural changes in attention and emotional processing (P300, LPP, frontal alpha asymmetry), physiological arousal (skin conductance), and visual attention biases (fixation duration and gaze distribution). The aim is to determine whether CBT leads to measurable improvements in neurobiological and attentional mechanisms related to body image disturbance and food-related anxiety in AN, contributing to biomarker-informed psychotherapy approaches.
Eligibility Criteria
Inclusion Criteria: * Female participants aged 18 to 35 * Meeting DSM-5 diagnostic criteria for restrictive-type anorexia nervosa * Body Mass Index (BMI) between 15.0 and 18.5 * Medically stable to participate in psychological and neurophysiological assessments * Willingness to participate in weekly therapy sessions (for the CBT group) and to complete pre- and post-assessments * Ability to provide informed consent Exclusion Criteria: * Current or past diagnosis of bulimia nervosa, binge-eating disorder, or other eating disorders * Presence of comorbid severe psychiatric disorders (e.g., psychosis, bipolar disorder, substance use disorder) * History of neurological illness or traumatic brain injury * Use of psychotropic medication within the last 6 weeks * Prior participation in structured Cognitive-Behavioral Therapy for an eating disorder * Pregnancy * Visual or neurological impairments that would prevent accurate EEG, GSR, or eye-tracking recordings
Contact & Investigator
Gökben Hızlı Sayar, Professor
STUDY CHAIR
Üsküdar University
Frequently Asked Questions
Who can join the NCT07037017 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 35 Years, studying Eating Disorders (Excluding Anorexia Nervosa). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07037017 currently recruiting?
Yes, NCT07037017 is actively recruiting participants. Contact the research team at metincinaroglu@gmail.com for enrollment information.
Where is the NCT07037017 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07037017 clinical trial?
NCT07037017 is sponsored by Istanbul Nisantasi University. The principal investigator is Gökben Hızlı Sayar, Professor at Üsküdar University. The trial plans to enroll 60 participants.