NCT06421987 Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
| NCT ID | NCT06421987 |
| Status | Recruiting |
| Phase | — |
| Sponsor | St. Jude Children's Research Hospital |
| Condition | Hodgkin Lymphoma, Adult |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2024-05-06 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2024-05-06 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
SURVIVORS Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors. Primary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. . Secondary Objectives To examine the degree of CO2 clearance (DLCO/ETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity. CONTROLS Volunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee/affiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.
Eligibility Criteria
Inclusion Criteria: HL Survivors * Completed bleomycin and/or thoracic radiation therapy for HL at SJCRH. * \<21-years old at diagnosis; currently ≥18-years of age and ≥2-years post therapy. * SJLIFE or ACT/SJLIFE participants * English language proficiency. Community Controls * SJLIFE control. * ≥18-years of age at the time of enrollment with age sampling to broadly match the HL survivors. Exclusion Criteria: HL Survivors * History of cranial or total-body irradiation therapy. * History of intrathecal or high dose intravenous antimetabolite therapy. * History of head injury or diagnosis of a genetic disorder associated with cognitive impairment.
Contact & Investigator
Nicholas Phillips, PhD
PRINCIPAL INVESTIGATOR
St. Jude
Frequently Asked Questions
Who can join the NCT06421987 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Hodgkin Lymphoma, Adult. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06421987 currently recruiting?
Yes, NCT06421987 is actively recruiting participants. Contact the research team at referralinfo@stjude.org for enrollment information.
Where is the NCT06421987 trial being conducted?
This trial is being conducted at Memphis, United States.
Who is sponsoring the NCT06421987 clinical trial?
NCT06421987 is sponsored by St. Jude Children's Research Hospital. The principal investigator is Nicholas Phillips, PhD at St. Jude. The trial plans to enroll 100 participants.