NCT05189262 Cardiopulmonary Bypass Induced Red Blood Cell Lysis
| NCT ID | NCT05189262 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Maryland, Baltimore |
| Condition | Cardiopulmonary Bypass |
| Study Type | OBSERVATIONAL |
| Enrollment | 150 participants |
| Start Date | 2022-03-22 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 150 participants in total. It began in 2022-03-22 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB. These results will be compared to existing laboratory-based methods for determining red blood cell damage to predict CPB assist device safety. Further, results from the studies described in this proposal will help develop therapeutic strategies to benefit patients by early detection of pfH and clearance protein levels that occur during CPB.
Eligibility Criteria
Inclusion Criteria: * Admitted to UMMC for cardiac procedure * Age: \>/=18 y.o TO 88 y.o. * Undergoing CPB \>1hr for the following surgeries (a) complex cardiac surgery (b) heart valve replacement surgery OR (c) CABG surgery. Exclusion Criteria: * Pregnant * Non English speaking * Unable to consent or have Legally Authorized Representative (LAR) assent to study
Contact & Investigator
Paul Buehler, PhD
PRINCIPAL INVESTIGATOR
University of Maryland
Frequently Asked Questions
Who can join the NCT05189262 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 88 Years, studying Cardiopulmonary Bypass. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05189262 currently recruiting?
Yes, NCT05189262 is actively recruiting participants. Contact the research team at pbuehler@som.umaryland.edu for enrollment information.
Where is the NCT05189262 trial being conducted?
This trial is being conducted at Baltimore, United States.
Who is sponsoring the NCT05189262 clinical trial?
NCT05189262 is sponsored by University of Maryland, Baltimore. The principal investigator is Paul Buehler, PhD at University of Maryland. The trial plans to enroll 150 participants.