NCT07518251 CompaRison of FEmorofemoral Bypass and Left-Heart ByPass Techniques in Open Thoracoabdominal AortIc Aneurysm Repair
| NCT ID | NCT07518251 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Beijing Anzhen Hospital |
| Condition | Thoracoabdominal Aortic Aneurysm |
| Study Type | INTERVENTIONAL |
| Enrollment | 236 participants |
| Start Date | 2026-04-20 |
| Primary Completion | 2028-03-20 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 236 participants in total. It began in 2026-04-20 with a primary completion date of 2028-03-20.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study is a multicenter, two-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 236 participants diagnosed with TAAA from 4 hospitals in China. All patients receive TAAAR procedure and are randomized to control group (LHB) and experimental group (fCPB) in the ratio of 1:1. After a 1-year follow-up, the validity and safety of the different cardiopulmonary bypass for TAAAR is evaluated via the incidence of major adverse events including surgical mortality, RRT, stroke, and SCI, as well as intraoperative blood product transfusion volume, mechanical ventilation, and early mortality.
Eligibility Criteria
Inclusion Criteria: 1. Computed tomography angiography (CTA) confirmed as ATAAD according to the 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease; 2. Adult patients (≥18 years old); 3. Indications for TAAAR are available and requiring cardiopulmonary bypass; 4. Signed informed consent and availability for follow-up. Exclusion Criteria: 1. History of chronic renal failure, chronic heart failure, Coronary heart disease with established surgical indications, hepatocirrhosis, and hepatic insufficiency; 2. History of severe cerebral infarction (with cerebral infarction sequels); 3. Inflammatory aortic diseases, such as Takayasu arteritis and Behçet's disease, etc; 4. History of infectious aortic diseases; 5. History of malignancy or previous radiotherapy; 6. Pregnant or feeding women, or anyone planning to reproduce during the test period; 7. Participating in any other clinical trial; 8. Having other causes not eligible for operation.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07518251 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Thoracoabdominal Aortic Aneurysm. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07518251 currently recruiting?
Yes, NCT07518251 is actively recruiting participants. Contact the research team at 15524612655@163.com for enrollment information.
Where is the NCT07518251 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT07518251 clinical trial?
NCT07518251 is sponsored by Beijing Anzhen Hospital. The trial plans to enroll 236 participants.