NCT05117424 CArdioMetabolism and Atherosclerotic PlaqUe progreSsion
| NCT ID | NCT05117424 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ruijin Hospital |
| Condition | Coronary Artery Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 3,000 participants |
| Start Date | 2017-01-01 |
| Primary Completion | 2025-12-31 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
Systematic metabolic diseases are closely related to prevalence and progression of atherosclerosis. This prospective cohort consecutively enrolls patients with coronary artery disease compliacted with metabolic abnormalities such as diabtetes, prediabetes, obesity, chronic kidney disease and hyperuricemia.
Eligibility Criteria
Inclusion Criteria: * Age 18-80 years * Established coronary artery disease or metabolic disorders, including: 1. Type 2 diabetes diagnosed by one of the following criteria: HbA1c \>/= 6.5% Fasting plasma glucose \>/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT \>/= 11.1 mmol/l Already receiving glucose-lowering agents 2. Prediabetes 3. Obesity 4. Chronic kidney disease 5. Hyperuricemia 6. Dyslipidemia Exclusion Criteria: * Severe liver failure (Child-Pugh grade B to C) * Severe anemia (hemoglobin \< 60g/L) * Familial hypercholesterolemia * Active malignant tumor * Active autoimmune diseases on corticosteroids * Acute or chronic infection * Life expectancy \< 1 year