NCT05765175 Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)
| NCT ID | NCT05765175 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Varian, a Siemens Healthineers Company |
| Condition | Tachycardia, Ventricular |
| Study Type | INTERVENTIONAL |
| Enrollment | 380 participants |
| Start Date | 2023-04-21 |
| Primary Completion | 2026-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 380 participants in total. It began in 2023-04-21 with a primary completion date of 2026-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
RADIATE-VT is a pivotal, multicenter, randomized trial comparing safety and efficacy between cardiac radioablation (CRA) using the Varian CRA System and repeat catheter ablation (CA), for patients with high-risk refractory ventricular tachycardia (VT) who have experienced VT recurrence after CA and are candidates for additional CA.
Eligibility Criteria
Inclusion Criteria: 1. High-risk refractory VT, defined as: 1. Ischemic and/or nonischemic cardiomyopathy, and 2. Recurrent sustained monomorphic VT, defined as at least one of the following below, documented by ICD interrogation or ECG in the prior 6 months, and having occurred after the last VT ablation: A: ≥3 episodes of monomorphic VT treated with anti-tachycardia pacing (ATP) at least one of which is symptomatic B: ≥1 appropriate ICD shock C: ≥3 episodes of sustained monomorphic VT within 24 hours treated with ICD shock or ATP D: sustained monomorphic VT below detection rate of ICD documented by ECG, and 3. Left ventricular ejection fraction (LVEF) ≤49% and 4. Previously underwent at least one standard of care CA for VT. 2. Presence of a clinical indication for a repeat CA procedure for scar-mediated VT in the judgement of the treating investigator. 3. Has failed amiodarone therapy or is intolerant to amiodarone: * Failed amiodarone therapy is defined as: appropriate ICD therapy or sustained monomorphic VT having occurred while the patient was taking amiodarone (minimum cumulative dose of 10 g). * Intolerant to amiodarone is defined as: previously tried or taken amiodarone but stopped due to medication related side effects or toxicities. 4. Deemed to be medically and technically a candidate for further CA by the electrophysiologist investigator. 5. Presence of an ICD. 6. At least 18 years of age (or meets local age of majority). 7. Ability to understand and willingness to sign an IRB approved written informed consent document. Exclusion Criteria: 1. Contraindication to a CA procedure for VT (e.g., presence of mobile LV thrombus, active systemic infection, active ischemic or other reversible causes of VT). 2. Patients with expected, right ventricular scar only. 3. Any prior radiation to the thorax region of the body. 4. Known medical conditions associated with higher risk of radiotherapy complications in the judgement of the radiation oncologist (i.e., active connective tissue disorders, interstitial lung disease, etc.) that would preclude safe delivery of CRA. 5. Current use of inotropes. 6. Presence of a left-ventricular assist device (LVAD). 7. Scheduled for LVAD or heart transplant procedures. 8. Presence of a systemic illness likely to limit survival to \< 1 year. 9. VT ablation procedure performed within the prior 2 weeks. 10. Polymorphic VT or ventricular fibrillation (VF) as the primary clinical heart rhythm, as indicated by 12-lead ECG and/or ICD interrogation. 11. \>3 distinct clinical monomorphic VT morphologies on ICD interrogation since the prior CA, or \>5 induced monomorphic VT morphologies during NIPS testing. 12. Incessant VT that is hemodynamically unstable. 13. Bundle branch reentry (BBR) VT. 14. Pregnant and/or breastfeeding. (Patient denial is sufficient for enrollment). 15. Patients of childbearing potential who: * are not on a medically effective means of birth control at the time of screening or do not start a medically effective means of birth control prior to randomization; or * do not agree to continue medically effective means of birth control until they have completed their assigned therapy; or * do not agree to be on a medically effective means of birth control if they are treated with CRA after their index CA procedure. 16. Patients enrolled in another clinical study the investigator believes to be in conflict with this clinical investigation. 17. Patients enrolled or planned to be enrolled in another cardiac radioablation clinical study or registry. 18. Patients with any other medical condition or laboratory value that would, at the discretion of the investigator, preclude the patient from participation in this clinical investigation.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05765175 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Tachycardia, Ventricular. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05765175 currently recruiting?
Yes, NCT05765175 is actively recruiting participants. Contact the research team at claire.mccann@varian.com for enrollment information.
Where is the NCT05765175 trial being conducted?
This trial is being conducted at Los Angeles, United States, Hartford, United States, Boston, United States, Rochester, United States and 7 additional locations.
Who is sponsoring the NCT05765175 clinical trial?
NCT05765175 is sponsored by Varian, a Siemens Healthineers Company. The trial plans to enroll 380 participants.