NCT06410157 Cardiac-Control Affecting Learning Through Mindfulness (CALM)
| NCT ID | NCT06410157 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Southern California |
| Condition | Age-related Cognitive Decline |
| Study Type | INTERVENTIONAL |
| Enrollment | 240 participants |
| Start Date | 2025-01-14 |
| Primary Completion | 2027-11 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 240 participants in total. It began in 2025-01-14 with a primary completion date of 2027-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.
Eligibility Criteria
Inclusion criteria * Fluent in English * Black/African-American or White/European-American * Aged between 50-70 years old * Non-pregnant and non-menstruating (for at least the past year) * Have normal or corrected-to-normal vision and hearing * Have reliable access to wifi * Have an email account that you check regularly * Have a phone that receives text messages * Agree to provide blood and urine samples at two campus visits * Agree to devote up to 50 minutes daily to this study for 10 weeks as well as attend two campus visits Exclusion criteria * Have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea) * Have cognitive impairment * Have regularly played Lumosity games in the past 6 months * Have any conditions listed below that are not safe for MRI * \*Metal in any parts of your body * Claustrophobia * Have worked as a machinist, metal worker, or in any profession or hobby grinding metal? * Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body) * Cardiac pacemaker * Implanted cardiac defibrillator * Aneurysm clip or brain clip * Carotid artery vascular clamp * Neurostimulator * Insulin or infusion pump * Spinal fusion stimulator * Cochlear, otologic, ear tubes or ear implant * Prosthesis (eye/orbital, penile, etc.) * Implant held in place by a magnet * Heart valve prosthesis * Artificial limb or joint * Other implants in body or head * Electrodes (on body, head or brain) * Intravascular stents, filters * Shunt (spinal or intraventricular) * Vascular access port or catheters * IUD * Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI * Shrapnel, buckshot, or bullets * Tattooed eyeliner or eyebrows * Body piercing(s) that cannot be removed for MRI * Metal fragments (eye, head, ear, skin) * Internal pacing wires * Aortic clips * Metal or wire mesh implants * Wire sutures or surgical staples * Harrington rods (spine) * Bone/joint pin, screw, nail, wire, plate * Wig or toupee that cannot be removed for MRI * Hair implants that involve staples or metal * Hearing aid(s) that cannot be removed for MRI * Dentures or retainers that cannot be removed for MRI
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06410157 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 70 Years, studying Age-related Cognitive Decline. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06410157 currently recruiting?
Yes, NCT06410157 is actively recruiting participants. Contact the research team at matherlab@usc.edu for enrollment information.
Where is the NCT06410157 trial being conducted?
This trial is being conducted at Los Angeles, United States.
Who is sponsoring the NCT06410157 clinical trial?
NCT06410157 is sponsored by University of Southern California. The trial plans to enroll 240 participants.