NCT04510025 Capturing MultiORgan Effects of COVID-19
| NCT ID | NCT04510025 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Oxford |
| Condition | Coronavirus Infection |
| Study Type | OBSERVATIONAL |
| Enrollment | 750 participants |
| Start Date | 2020-05-13 |
| Primary Completion | 2026-05-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 750 participants in total. It began in 2020-05-13 with a primary completion date of 2026-05-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The C-MORE study is prospective observational holistic longitudinal study which will characterise the prevalence of multi-organ injury among COVID-19 survivors post hospital discharge and assess its effects on quality of life, exercise tolerance and mental health.
Eligibility Criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 years or above. * Diagnosis of COVID-19 infection confirmed by detection of viral nucleic acid on reverse-transcription Polymerase Chain Reaction (RT-PCR). * Infection should be of moderate to severe intensity (i.e, patients with clinical signs of pneumonia such as respiratory rate \> 30 breaths/min; or severe respiratory distress; or SpO2 \< 90% (on room air) and admission for \>48 hours. * Controls: Participants with no serological evidence of previous infection, or active/previous symptoms suggestive of COVID-19, and who may or may not have comorbidities. Exclusion Criteria: * Contraindication to MRI e.g. pregnancy, pacemaker, ferromagnetic implant, shrapnel injury, severe claustrophobia, inability to lie flat. * Any other significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study. * Any signs of active COVID-19 infection on day of visit. * Significantly impaired renal function (eGFR\<30 ml/min)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT04510025 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 100 Years, studying Coronavirus Infection. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04510025 currently recruiting?
Yes, NCT04510025 is actively recruiting participants. Contact the research team at betty.raman@cardiov.ox.ac.uk for enrollment information.
Where is the NCT04510025 trial being conducted?
This trial is being conducted at Oxford, United Kingdom.
Who is sponsoring the NCT04510025 clinical trial?
NCT04510025 is sponsored by University of Oxford. The trial plans to enroll 750 participants.