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Recruiting Phase 4 NCT06934057

Cabozantinib and Nivolumab Among Older Patients With Renal Cell Carcinoma

Trial Parameters

Condition Kidney Cancer
Sponsor Gustave Roussy, Cancer Campus, Grand Paris
Study Type INTERVENTIONAL
Phase Phase 4
Enrollment 50
Sex ALL
Min Age 70 Years
Max Age N/A
Start Date 2025-05-16
Completion 2028-04
Interventions
NivolumabCabozantinib

Brief Summary

The goal of the study is to describe real-life use and exposition to nivolumab-cabozantinib among older patients with metastatic clear-cell renal cell cancer

Eligibility Criteria

Inclusion Criteria: 1. Patients ≥ 70 years-old 2. Confirmed advanced or metastatic renal-cell carcinoma 3. Patients not previously treated in metastatic setting 4. Performance Status 0 to 2 5. Sexually active male patients must agree to use condom during the study and for at least 5 months after the last study treatment administration. Also, it is recommended their women of childbearing potential partner use a highly effective method of contraception. 6. Patient should understand, sign, and date the written informed consent form prior to any protocol-specific procedures performed. Patient should be able and willing to comply with study visits and procedures as per protocol. 7. Patients must be affiliated to a social security system or beneficiary of the same Exclusion Criteria: 1. Participation in another clinical study with an investigational product during the last four weeks and while on study treatment (Patients may be included in CABOLD if they are included in the arm B of CARE1 s

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