NCT07151677 Brain Stimulation Effects on Post-Stroke Fatigue and Aphasia
| NCT ID | NCT07151677 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Syracuse University |
| Condition | Aphasia Following Cerebral Infarction |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-08-04 |
| Primary Completion | 2029-09 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-08-04 with a primary completion date of 2029-09.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to determine if electrical brain stimulation applied to the front parts of the brain can help people who have had a stroke improve their fatigue, language, and attention. The main question it aims to answer is: * Does transcranial direct current stimulation (tDCS) administered to the pre-frontal areas of the brain improve post-stroke fatigue and aphasia? * What kinds of participant characteristics are associated with better improvement of post-stroke fatigue and aphasia? Researchers will compare active electrical stimulation to sham stimulation to see if the active stimulation does a better job at reducing fatigue and language deficits after stroke. Participants will be asked to complete fatigue, language, and cognitive testing before and after receiving 10 sessions of tDCS plus speech and language therapy.
Eligibility Criteria
Inclusion Criteria: 1. 18 years or older. 2. No diagnosis of neurological disorder (other than stroke). 3. No diagnosis of psychiatric disorder, with the exception of anxiety and/or depression if it is managed through medication and/or behavioral intervention. 4. No seizure within the past 6 months. 5. Not pregnant. 6. Does not currently have cardiac pacemaker 7. In chronic phase of recovery, defined as at least 6 months post-stroke. 8. Not undergoing speech and language therapy targeting auditory comprehension or attention for the duration of the study. 9. No metal implants in the scalp or bone in the pre-frontal area of the head. 10. No unhealed skull fractures. 11. Onset of aphasia related to single, left hemisphere, ischemic stroke. 12. Damaged brain tissue from stroke does not overlap with left hemisphere dorsolateral prefrontal cortex. 13. Mild to moderate aphasia (as measured by WAB-R \*\*or QAB). 14. Self-report of post-stroke fatigue (as measured on SF-CAT) 15. No significant challenges with vision or hearing (with use of corrective aids if needed; eyeglasses, hearing aids). 16. Willing to allow audio-recording of study sessions. Exclusion Criteria: 1. Younger than 18 years old. 2. Diagnosis or history of neurological disorder other than stroke. 3. Diagnosis or history of psychiatric disorder with the exception of anxiety and/or depression if it is managed through medication and/or behavioral intervention. 4. History of seizures within the past 6 months. 5. Pregnant. 6. Currently has cardiac pacemaker 7. \<6 months post-stroke (however, if this is only exclusionary criterion met, participant can be re-evaluated at the 6-month mark if still interested in the study) 8. Currently undergoing speech and language therapy targeting auditory comprehension or attention. 9. Metal implants in the scalp or bone in the pre-frontal area of the head. 10. Currently has an unhealed skull fracture. 11. Onset of aphasia related to etiology other than ischemic left hemisphere stroke. 12. Damaged brain tissue significantly overlaps with left hemisphere dorsolateral prefrontal cortex. 13. No aphasia or severe aphasia (as measured by WAB-R \*\*or QAB). 14. Does not report experience of post-stroke fatigue (as measured on SF-CAT) 15. Significant challenges with vision and/or hearing (even with use of corrective aids). 16. Unwilling to allow audio-recording of study sessions.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07151677 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Aphasia Following Cerebral Infarction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07151677 currently recruiting?
Yes, NCT07151677 is actively recruiting participants. Contact the research team at aphasia@syr.edu for enrollment information.
Where is the NCT07151677 trial being conducted?
This trial is being conducted at Ann Arbor, United States, Syracuse, United States.
Who is sponsoring the NCT07151677 clinical trial?
NCT07151677 is sponsored by Syracuse University. The trial plans to enroll 60 participants.