Brain Neuronal Networks, Chemosensory and Trigeminal Functions in Allo-HSCT
Trial Parameters
Brief Summary
The goal of this prospective, cohort study is to learn about smell, taste and trigeminal dysfunction in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The research team hypothesizes that treatment with allo-HSCT will induce: * Distortion of taste and smell and trigeminal functions like cooling, tingling, and burning sensations. * Reduced saliva production leading to oral dryness and dental caries. * Changes in the connectivity of the taste-, smell- and pain-cortical brain regions.
Eligibility Criteria
Inclusion Criteria: • patients receiving myeloablative conditioning for a first-time allo-HSCT and diagnosed with either a leukemia or a myelodysplastic syndrome Exclusion Criteria: * disorders affecting the oral cavity including poor tooth-status * those using drugs affecting the gustatory/olfactory functions * those with brain disorders * those who have a chronic disorder affecting the immune system, have cancer or who are pregnant.