| NCT ID | NCT07624747 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Wisconsin, Madison |
| Condition | Gender Dysphoria |
| Study Type | OBSERVATIONAL |
| Enrollment | 72 participants |
| Start Date | 2025-10-14 |
| Primary Completion | 2028-04 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 72 participants in total. It began in 2025-10-14 with a primary completion date of 2028-04.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to test whether and how a person's brain changes in the first few months after starting gender affirming hormone therapy (GAHT). The investigators want to know if GAHT changes: 1) cerebral blood flow (CBF), 2) brain structure, connectivity, and cognitive task performance, and 3) neurocognitive function (memory, attention, executive function, processing speed). 36 male at birth and 36 female at birth participants will conduct baseline studies prior to GAHT, with a second identical set of study visits 4-6 months after GAHT begins.
Eligibility Criteria
Inclusion Criteria: * intention to undergo GAHT Exclusion Criteria: * BMI greater than 40 kg/m2 * Age greater than 45 yrs * Blood pressure greater than 140/90 (stage II hypertension) * A current diagnosis of type II diabetes * History of traumatic brain injury/concussion, stroke, or seizures * Are post-menopausal * Previously taken hormone therapy medications * Self-reported pregnancy (no pregnancy test)
Contact & Investigator
William Schrage, PhD
PRINCIPAL INVESTIGATOR
University of Wisconsin, Madison
Frequently Asked Questions
Who can join the NCT07624747 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 45 Years, studying Gender Dysphoria. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07624747 currently recruiting?
Yes, NCT07624747 is actively recruiting participants. Contact the research team at sbolin@wisc.edu for enrollment information.
Where is the NCT07624747 trial being conducted?
This trial is being conducted at Madison, United States.
Who is sponsoring the NCT07624747 clinical trial?
NCT07624747 is sponsored by University of Wisconsin, Madison. The principal investigator is William Schrage, PhD at University of Wisconsin, Madison. The trial plans to enroll 72 participants.