NCT07671963 Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial
| NCT ID | NCT07671963 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Belgrade |
| Condition | Periodontitis (Stage 3) |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2026-07-01 |
| Primary Completion | 2027-02-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2026-07-01 with a primary completion date of 2027-02-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with the Non-Incised Papilla Surgical Approach (NIPSA) for the treatment of intrabony periodontal defects. The study will evaluate whether differences exist between the two biomaterials with respect to clinical attachment gain, defect resolution, wound healing and biological markers of regeneration.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years * Diagnosis of Stage III periodontitis * At least one intrabony periodontal defect with probing depth \> 5 mm following completion of non-surgical periodontal therapy * Full-mouth plaque score (FMPS) \< 20% * Full-mouth bleeding score (FMBS) \< 20% * Ability to understand the study procedures and provide written informed consent Exclusion Criteria: * Systemic medical contraindications to periodontal surgery * History of head and neck radiotherapy * Poor oral hygiene or lack of motivation/compliance * Uncontrolled diabetes mellitus * Pregnancy or lactation * Treatment with antiresorptive medications or other drugs affecting bone remodeling * Heavy smoking (\>20 cigarettes/day)
Contact & Investigator
Iva Z Milinkovic, DDS, PhD
PRINCIPAL INVESTIGATOR
School of Dental Medicine, University of Belgrade, Implant Research Centre and Department of Periodontology and Oral Medicine
Frequently Asked Questions
Who can join the NCT07671963 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Periodontitis (Stage 3). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07671963 currently recruiting?
Yes, NCT07671963 is actively recruiting participants. Contact the research team at iva.milinkovic@gmail.com for enrollment information.
Where is the NCT07671963 trial being conducted?
This trial is being conducted at Cagliari, Italy, Belgrade, Serbia.
Who is sponsoring the NCT07671963 clinical trial?
NCT07671963 is sponsored by University of Belgrade. The principal investigator is Iva Z Milinkovic, DDS, PhD at School of Dental Medicine, University of Belgrade, Implant Research Centre and Department of Periodontology and Oral Medicine. The trial plans to enroll 30 participants.