Trial Parameters
Brief Summary
The macronutrient composition of our diet (proportions of carbohydrates, fats and proteins) strongly influences the way our body stores and utilises substrates (e.g., fats and sugars), which in turn influences our risk of developing cardiometabolic diseases (e.g., coronary artery disease or insulin resistance). The optimal dietary composition to lower the risk of cardiometabolic disease is unknown. In a randomized, parallel design, this study will investigate how the overconsumption of carbohydrates and fats affects blood lipid responses and liver metabolism in adults free from metabolic disease. By genotyping participants, we will also examine the interaction between macronutrient content and an individual's genes on blood lipid responses and liver metabolism.
Eligibility Criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged ≥18 to ≤65 years * Body mass index (BMI) ≥19 to ≤35 kg/m2 * No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism. * Weight stable for the previous 3 months Exclusion Criteria: * Aged \<18 or \>65 years * BMI \<19 or \>35 kg/m2 * A blood haemoglobin \<135 mg/dL for men and \<120 mg/dL for women * Donated (or lost) ≥250 mL of blood in the previous two months * On a weight loss diet or decreased their body weight by \>5% in the previous 3 months * Currently adhering to or have consumed in the previous 3 months a diet with a notably altered macro-nutrient content (e.g. high-fat - low-carbohydrate diet) * Have increased their body weight by \>5% in the previous 3 months * Any metabolic condition or relevant drug therapy * Current smoker * History of alcoholism or a greater than recommended alco