NCT06508801 Blood Flow Restriction for Optimizing Balance in Parkinson's Disease
| NCT ID | NCT06508801 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The University of Texas Health Science Center at San Antonio |
| Condition | Parkinson's Disease and Parkinsonism |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2025-01-07 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2025-01-07 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson's disease.
Eligibility Criteria
Inclusion Criteria: 1. Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria, 2. in Hoehn and Yahr stage 2-4, 3. a score of ≥23 on the mini-Mental Scale Examination. Exclusion Criteria: 1. History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis; 2. Ankle branchial index ≤ 0.9 or \> 1.3. 3. History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis or muscle disease such as muscular dystrophy, myopathy. 4. History of uncontrolled diabetes, severe osteoporosis, or cognitive impairment. 5. Body mass index above 40; such individuals are more likely to have poorer muscle function and more pain. 6. Absolute contraindications to exercise as per the American College of Sports Medicine (uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram (EKG) changes, unstable angina, acute myocardial infarction, or acute congestive heart failure 7. Had surgery in the lower extremities within the past 6 months. 8. Pre-menopausal and not on birth control 9. Pregnant or planning to become pregnant within the course of the study 10. Plan to have major surgery within 2 months.
Contact & Investigator
Anjali Sivaramakrishnan, PhD, PT
PRINCIPAL INVESTIGATOR
The University of Texas Health Science Center at San Antonio
Frequently Asked Questions
Who can join the NCT06508801 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, up to 85 Years, studying Parkinson's Disease and Parkinsonism. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06508801 currently recruiting?
Yes, NCT06508801 is actively recruiting participants. Contact the research team at sivaramakris@uthscsa.edu for enrollment information.
Where is the NCT06508801 trial being conducted?
This trial is being conducted at San Antonio, United States.
Who is sponsoring the NCT06508801 clinical trial?
NCT06508801 is sponsored by The University of Texas Health Science Center at San Antonio. The principal investigator is Anjali Sivaramakrishnan, PhD, PT at The University of Texas Health Science Center at San Antonio. The trial plans to enroll 20 participants.
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