NCT06027294 Blood Flow Regulation and Neuromuscular Function Post-Stroke
| NCT ID | NCT06027294 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical College of Wisconsin |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2024-01-11 |
| Primary Completion | 2028-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2024-01-11 with a primary completion date of 2028-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.
Eligibility Criteria
Inclusion Criteria: * Be between 18-85 years of age * Able to give informed consent * ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke * English speaking Exclusion Criteria: * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg) * Chronic pain syndrome * Low back or hip pain that interferes with lower extremity motor testing * History of head trauma * Comorbid neurological disorder * Peripheral vascular disease * Myocardial infarction in the previous year * Inability to follow 2 step commands * Condition where fatiguing contractions or resisted leg contractions are contraindicated * Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg * Pregnancy or breastfeeding.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06027294 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 85 Years, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06027294 currently recruiting?
Yes, NCT06027294 is actively recruiting participants. Contact the research team at mdurand@mcw.edu for enrollment information.
Where is the NCT06027294 trial being conducted?
This trial is being conducted at Milwaukee, United States, Milwaukee, United States.
Who is sponsoring the NCT06027294 clinical trial?
NCT06027294 is sponsored by Medical College of Wisconsin. The trial plans to enroll 40 participants.
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