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Recruiting NCT06492538

Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study

Trial Parameters

Condition Angle-closure Glaucoma
Sponsor Zhongshan Ophthalmic Center, Sun Yat-sen University
Study Type OBSERVATIONAL
Phase N/A
Enrollment 300
Sex ALL
Min Age 30 Years
Max Age 85 Years
Start Date 2023-12-01
Completion 2025-12-30
Interventions
various types of angle interventions

Brief Summary

The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma. Minimally invasive glaucoma surgery, particularly angle surgery, has advanced recently, allowing clear visualization of angle structures like the trabecular meshwork and Schlemm's canal using surgical goniolens. Techniques for angle intervention include widening the angle, reopening closed angles, and rebuilding outflow pathways using methods such as laser peripheral iridotomy, Argon laser peripheral iridoplasty, and mechanical separation of adhered tissues. Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery, aiming to support innovation and standardization of minimally invasive angle surgery.

Eligibility Criteria

Inclusion Criteria: * Glaucoma patients eligible for standalone or combined angle intervention surgeries, such as LPI, LPIP, goniosynechialysis, trabeculotomy alone or combined with surgical iridectomy or phacoemulsification and intraocular lens implantation; * Patients capable of undergoing preoperative examinations including CASIA2-OCT (anterior segment OCT), UBM, slit-lamp gonioscopy, IOL Master (or other optical biometry); * Patients willing to participate in this study, signing informed consent, and agreeing to follow-up according to the study protocol. Exclusion Criteria: * Patients with severe ocular conditions such as corneal infection, ulcer, trauma, ocular tumors, retinal vascular occlusion, and retinal detachment; * Those with various types of eye diseases that affect ocular parameter acquisition or interfere with visual field examination; * Long-term local or systemic use of glucocorticoids; * Patients with severe systemic diseases; * Pregnant or lactating women; * Unable t

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