Biomarker Profiling in Abdominal Aortic Aneurysm Patients
Trial Parameters
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Brief Summary
The BIOMArCS-AAA study aims to investigate the associations of (temporal patterns of) blood biomarkers with aneurysm growth in patients with abdominal aortic aneurysm (AAA), with particular attention to biomarkers that have demonstrated prognostic value for adverse disease outcomes in coronary artery disease and biomarkers for the main genetic pathways associated with AAA.
Eligibility Criteria
Inclusion Criteria: * Age of 18 years or older * Capable of understanding and signing informed consent AND one of the following 1. Diagnosis of AAA, with a diameter ≥40mm, based on any imaging technique and treated by watchful waiting strategy (Prospective longitudinal study, Arm 1 watchful waiting group) 2. Planned to undergo EVAR for AAA (Prospective longitudinal study, Arm 2 EVAR group) 3. Underwent EVAR for AAA in past years (Cross-sectional study) Exclusion Criteria: * Patients with isolated iliac artery aneurysm, traumatic aneurysm, anastomotic aneurysm and infectious aneurysm * Patients with a clinical diagnosed thoracic aneurysm (i.e. located in the chest, above the diaphragm) * Coexistent condition with life expectancy ≤ 1 year * Dialysis dependent, (end stage) renal disease patients * Women of childbearing age * Linguistic barrier * Unlikely to appear at all scheduled follow-up visits