NCT07641933 Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
| NCT ID | NCT07641933 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | Ain Shams University |
| Condition | Intervention Studies |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-06-01 |
| Primary Completion | 2027-06 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 60 participants in total. It began in 2026-06-01 with a primary completion date of 2027-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications: 1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite 2. Calcium Silicate 3. Calcium Hydroxide In retreatment cases in terms of: 1. Biological Evaluation: Biomarker (IL 1B) 2. Radiographic Evaluation: CBCT 3. Clinical Evaluation: Pain Score (VAS)
Eligibility Criteria
Inclusion Criteria: 1. Age: 21-45 years. 2. Medically free patients. (ASA Class 1) 3. Gender: males and females 4. Patients who are cooperative at operation and in attendance at scheduled follow-up visits. 5. Restorable root canal treated permanent lower first molars with periapical lesions. 6. Small (\<5 mm) or medium periapical lesion size (5-10 mm) Exclusion Criteria: 1. Patients with a history of allergic reactions to any of the study materials. 2. Teeth that become non-restorable after complete caries excavation. 3. Teeth that have mobility or deep periodontal pockets. 4. Teeth with internal or external resorption.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07641933 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 45 Years, studying Intervention Studies. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07641933 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT07641933 currently recruiting?
Yes, NCT07641933 is actively recruiting participants. Contact the research team at mernabotros@dent.asu.edu.eg for enrollment information.
Where is the NCT07641933 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07641933 clinical trial?
NCT07641933 is sponsored by Ain Shams University. The trial plans to enroll 60 participants.