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Recruiting NCT02292641

NCT02292641 Beyond TME Origins

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Clinical Trial Summary
NCT ID NCT02292641
Status Recruiting
Phase
Sponsor Imperial College London
Condition Neoplasms
Study Type INTERVENTIONAL
Enrollment 383 participants
Start Date 2014-09-25
Primary Completion 2026-12

Eligibility & Interventions

Sex All sexes
Min Age 16 Years
Max Age N/A
Study Type INTERVENTIONAL
Interventions
New Radiological Staging Classification system for patients with advanced and recurrent colorectal cancer undergoing pelvic exenterative surgery

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

This trial targets 383 participants in total. It began in 2014-09-25 with a primary completion date of 2026-12.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

All patients with recurrent colorectal cancer in the pelvis are eligible. The original primary tumour staging scans and resected surgical specimen needs to be available. Patients' recurrence will be staged using our proposed MRI classification. We will be assessing the original primary staging scans and histopathology to learn about risk factors for recurrence. We will record treatment for the recurrence, and patients will be followed up for three years.

Eligibility Criteria

Inclusion Criteria: 1. Had a primary colorectal adenocarcinoma proven by biopsy taken as part of routine clinical practice 2. Has a confirmed diagnosis of recurrent pelvic colorectal cancer 3. Has previously completed surgical treatment of primary adenocarcinoma of the colon, sigmoid colon or rectum 4. Are able to undergo high resolution MRI for staging prior to treatment decisions 5. Have provided written informed consent to participate in the study 6. Be aged 16 years or over Exclusion Criteria: 1. Have irresectable extra-pelvic metastatic disease 2. Original baseline staging and preoperative restaging scans (MR for rectal and sigmoid cancers and/or CT for colon and sigmoid cancers) are unavailable 3. Original preoperative, surgical and adjuvant treatment has not been documented or is unavailable

Contact & Investigator

Central Contact

Caroline Martin

✉ c.martin1@imperial.ac.uk

📞 +44 (0) 7749 655 817

Principal Investigator

Gina Dr Brown, MD

PRINCIPAL INVESTIGATOR

Imperial College London

Frequently Asked Questions

Who can join the NCT02292641 clinical trial?

This trial is open to participants of all sexes, aged 16 Years or older, studying Neoplasms. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT02292641 currently recruiting?

Yes, NCT02292641 is actively recruiting participants. Contact the research team at c.martin1@imperial.ac.uk for enrollment information.

Where is the NCT02292641 trial being conducted?

This trial is being conducted at Oslo, Norway, Harrow, United Kingdom, Oxford, United Kingdom, Sutton, United Kingdom.

Who is sponsoring the NCT02292641 clinical trial?

NCT02292641 is sponsored by Imperial College London. The principal investigator is Gina Dr Brown, MD at Imperial College London. The trial plans to enroll 383 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology