NCT06682481 Beta-Cell - Liver Interactions in Situations of Modified Beta-Cell Function
| NCT ID | NCT06682481 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Philippe Klee, MD-PhD |
| Condition | Obesity, Childhood |
| Study Type | OBSERVATIONAL |
| Enrollment | 50 participants |
| Start Date | 2024-11-22 |
| Primary Completion | 2028-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 50 participants in total. It began in 2024-11-22 with a primary completion date of 2028-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The investigators will measure blood levels of 1,5-anhydroglucitol in obese children with or without type 2 diabetes and correlate them with parameters related to functional beta-cell mass and glucose metabolism. The values will be compared to those obtained in healthy volunteers. The aim of the study is to test the validity of 1,5-anhydroglucitol as a novel biomarker of beta-cell mass and function in children with obesity with or without type 2 diabetes.
Eligibility Criteria
Inclusion Criteria: * Children aged 12 to 16 years * Obesity. Defined as a body-mass index above the 97th percentile. * Ability to give informed consent as documented by signature Exclusion Criteria: * Patients with diabetes mellitus and positive autoantibodies against islets, insulin, islet antigen 2, glutamic acid decarboxylase or Zinc transporter 8. * Patients with known liver disease (other than NAFLD) * Patients treated with an oral antidiabetic drug, glucagon-like peptide-1 analogues or insulin at the time of or less than 2 weeks prior to inclusion. * Patients treated with a drug known to affect liver function
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06682481 clinical trial?
This trial is open to participants of all sexes, aged 12 Years or older, up to 16 Years, studying Obesity, Childhood. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06682481 currently recruiting?
Yes, NCT06682481 is actively recruiting participants. Contact the research team at philippe.klee@unige.ch for enrollment information.
Where is the NCT06682481 trial being conducted?
This trial is being conducted at Geneva, Switzerland.
Who is sponsoring the NCT06682481 clinical trial?
NCT06682481 is sponsored by Philippe Klee, MD-PhD. The trial plans to enroll 50 participants.
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