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Recruiting NCT03460327
Bariatric Surgery and Pharmacokinetics of Candesartan
Trial Parameters
Condition Obesity, Morbid
Sponsor Norwegian University of Science and Technology
Study Type OBSERVATIONAL
Phase N/A
Enrollment 12
Sex ALL
Min Age 18 Years
Max Age 70 Years
Start Date 2016-11-02
Completion 2026-10
Interventions
Candesartan
Brief Summary
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on candesartan are investigated.
Eligibility Criteria
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract