NCT07005505 Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults
| NCT ID | NCT07005505 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Rush University Medical Center |
| Condition | Spontaneous Breathing Trial in ICU |
| Study Type | INTERVENTIONAL |
| Enrollment | 880 participants |
| Start Date | 2025-06-01 |
| Primary Completion | 2027-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 880 participants in total. It began in 2025-06-01 with a primary completion date of 2027-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.
Eligibility Criteria
Inclusion Criteria: * Admitted to intensive care unit (ICU) * Age 18 years or older * Requiring invasive mechanical ventilation for at least 24 hours * Pass spontaneous breathing trial screen criteria Exclusion Criteria: * Do not intubate (DNI) order * Presence of tracheostomy * Pregnancy * Known prisoner * Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures * Enrolled in another clinical trial that impacts ventilator weaning or liberation * Receive veno-venous extracorporeal membrane oxygenation (VV-ECMO)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07005505 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Spontaneous Breathing Trial in ICU. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07005505 currently recruiting?
Yes, NCT07005505 is actively recruiting participants. Contact the research team at Jie_Li@rush.edu for enrollment information.
Where is the NCT07005505 trial being conducted?
This trial is being conducted at Chicago, United States.
Who is sponsoring the NCT07005505 clinical trial?
NCT07005505 is sponsored by Rush University Medical Center. The trial plans to enroll 880 participants.