NCT06962644 Association of Urinary Tract Infection With Preeclampsia During Pregnancy
| NCT ID | NCT06962644 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Pakistan Air Force (PAF) Hospital Islamabad |
| Condition | Urinary Tract Infection (Diagnosis) |
| Study Type | OBSERVATIONAL |
| Enrollment | 160 participants |
| Start Date | 2025-01-01 |
| Primary Completion | 2025-04-30 |
Trial Parameters
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Brief Summary
Urinary tract infections (UTIs) are a major clinical issue, especially in pregnant women, due to physiological changes that increase susceptibility. If untreated, UTIs can lead to severe complications like preterm labor and low birth weight. Preeclampsia, a hypertensive disorder affecting 0.2-9.2% of pregnancies, is another leading cause of maternal and fetal complications. The relationship between UTIs and preeclampsia remains controversial, with some studies suggesting an association while others show conflicting results. Research gaps highlight the need for region-specific studies, particularly in Pakistan, where both conditions contribute significantly to maternal and neonatal morbidity. This study aims to investigate the association between UTIs and preeclampsia in pregnant women in Pakistan. It will use a cohort design, enrolling 160 patients (80 with UTIs, 80 without) from the Obstetrics Department of PAF Hospital, Islamabad. Participants will be followed until delivery, with preeclampsia diagnosed based on blood pressure and proteinuria criteria. Data will be analyzed using SPSS to calculate relative risk (RR), with statistical significance set at RR \>1 and p ≤ 0.05. The findings could help improve prenatal care and reduce adverse outcomes in high-risk populations.
Eligibility Criteria
Inclusion Criteria: * Patients attending OPD for routine antenatal checkup * Patients diagnosed with UTI as per operational definitions * Gestational age greater than 20 weeks as per LMP * Age between 18 to 35 years Exclusion Criteria: * History of medical conditions such as: * Diabetes mellitus * Chronic hypertension * Chronic liver or kidney diseases * Chronic pulmonary conditions * History of urological surgical interventions in the past 3 months * History of renal transplants * Patients on immunosuppressive therapy * History of comorbid conditions including: * Diabetes mellitus * Gestational diabetes mellitus * Hypertension * Chronic hepatic diseases * Chronic liver diseases * Chronic pulmonary diseases * Ischemic heart diseases