Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction
Trial Parameters
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Brief Summary
A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including recurrent implantation failure (RIF) after assisted reproductive technology (ART) (including IVF, ICSI and FET), recurrent pregnancy loss (RPL) after spontaneous conception, and RPL after ART.
Eligibility Criteria
Inclusion Criteria: fulfil one of the following: * 3 consecutive pregnancy losses after spontaneous conception * 3 consecutive pregnancy losses after assisted reproductive technology treatment (ART) including IVF, ICSI and FET * 3 failed embryo transfers characterized by no achieved pregnancy (after 3 cycles with minimum 1 embryo transfer of a good-quality embryo in each cycle.) Exclusion Criteria: * Age \<18 or \>45 years * AMH \<4.0 pmol/l unless donor egg in previous cycles * Significant uterine malformation * Known endometrial pathologies including intrauterine endometriosis, adenomyosis, hyperplasia or polyps * Known chromosomal abnormalities * Pregnancy \>9 weeks of gestation at the time collecting the blood sample