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Recruiting Phase 2 NCT06339580
Assessment of Volume-targeted Ventilation in Patients With Neuromuscular Disease
Trial Parameters
Condition Neuromuscular Diseases
Sponsor Guy's and St Thomas' NHS Foundation Trust
Study Type INTERVENTIONAL
Phase Phase 2
Enrollment 30
Sex ALL
Min Age 18 Years
Max Age 80 Years
Start Date 2024-04-09
Completion 2026-03
Interventions
Volume-targeted non-invasive ventilation
Brief Summary
Assessment of safety and efficacy of volume-targeted ventilation in patients with neuromuscular disease.
Eligibility Criteria
Inclusion Criteria: * Slowly progressive neuromuscular disease * Established on fixed bi-level ventilation * Documented clinical respiratory stability by supervising clinician (no hospitalizations, respiratory infections or change to ventilator settings in preceding 6 weeks) Exclusion Criteria: * Rapidly progressive neuromuscular disease * Decompensated respiratory failure (pH \< 7.35) * Pregnancy * Aged \<18, \>80 * Poor adherence to NIV (\<4hrs per night) * Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol