Assessment of Volatile Organic Compounds (VOC) for the Diagnosis of Invasive Aspergillosis (IA) in Lung Transplant Recipients
Trial Parameters
Brief Summary
Prospective observational pilot study to evaluate the utility of breath VOCs to detect invasive aspergillosis in lung transplant recipients that are suspected of invasive fungal disease (IFD).
Eligibility Criteria
Inclusion Criteria: Patients with the following criteria will be included in the study: 1. Over the age of 18 years 2. Recipient of single/double lung transplant 3. Willingness to participate in the study 4. Suspected of invasive fungal disease or undergo surveillance appointments 5. Capable of providing sample 6. Capable of providing consent \- Exclusion Criteria: Patients with the following criteria will be excluded from the study: 1. On mechanical ventilation, oxygen supplementation including nasal cannula; simple, fixed, or non-rebreathing face mask at presentation. 2. Admitted to the intensive care unit at presentation. 3. The subject is currently diagnosed with a confirmed bacterial or viral respiratory infection or has received a diagnosis of a respiratory viral or bacterial infection within the last 4 weeks. 4. Previous diagnosis of Cystic Fibrosis 5. Use of antifungals in previous 4 weeks 6. Has been previously diagnosed with respiratory fungal infection other than aspergillus