NCT03344276 Assessing Neurocognition After Cerebrovascular Intervention
| NCT ID | NCT03344276 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, San Diego |
| Condition | Carotid Artery Diseases |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2021-07-15 |
| Primary Completion | 2025-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2021-07-15 with a primary completion date of 2025-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.
Eligibility Criteria
Inclusion Criteria: * patients \>18 years of age * ultrasound evidence of carotid stenosis; in which the patient has either 50% or greater symptomatic carotid stenosis or 70% or greater asymptomatic carotid stenosis. Exclusion Criteria: 1. patients \<18 years of age 2. patients with without compatibility for MRI 3. patients requiring carotid stenting for reasons not related to long-standing stenosis 4. patients requiring emergency carotid stenting for acute symptoms such as crescendo transient ischemic attacks, intolerance of physiologic blood pressure. 5. Patients that do not have appropriate capacity (i.e. understand the risks and benefits associated with this study) or are unable to consent for themselves will not be included in this study.
Contact & Investigator
Alexander A Khalessi, MD
PRINCIPAL INVESTIGATOR
UC San Diego
Frequently Asked Questions
Who can join the NCT03344276 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Carotid Artery Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03344276 currently recruiting?
Yes, NCT03344276 is actively recruiting participants. Contact the research team at akhalessi@ucsd.edu for enrollment information.
Where is the NCT03344276 trial being conducted?
This trial is being conducted at San Diego, United States.
Who is sponsoring the NCT03344276 clinical trial?
NCT03344276 is sponsored by University of California, San Diego. The principal investigator is Alexander A Khalessi, MD at UC San Diego. The trial plans to enroll 20 participants.