NCT07562451 Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
| NCT ID | NCT07562451 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Emory University |
| Condition | Sickle Cell Disease |
| Study Type | INTERVENTIONAL |
| Enrollment | 25 participants |
| Start Date | 2026-09-01 |
| Primary Completion | 2028-04-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 25 participants in total. It began in 2026-09-01 with a primary completion date of 2028-04-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to evaluate whether a 4-week music therapy (MT) intervention can reduce chronic pain and improve psychosocial outcomes in youth with sickle cell disease (SCD). The main questions it aims to answer are: * Does MT reduce pain intensity, frequency of pain episodes, and improve health-related quality of life (HRQoL)? * Does MT alter immune cell composition and gene expression in inflammatory pathways, as measured by single-cell RNA sequencing (scRNA-seq)? Researchers will compare participants randomized to music therapy versus a control condition to see if MT produces superior improvements in pain and psychosocial outcomes, and distinct molecular changes.
Eligibility Criteria
Inclusion Criteria: * Diagnosed with SCD * English fluency (for survey completion) * Have access to a personal electronic device (e.g., phone, tablet) with access to the internet * Meet the criteria for chronic pain defined by the International Association for the Study of Pain (IASP). IASP defines chronic pain as pain that is both: 1. Persistent or recurrent for ≥ 3 months 2. is associated with significant emotional distress or functional disability.30 Exclusion Criteria: * Major hearing deficiency or medical condition in which listening to music may be contraindicated (e.g., reflex epilepsy).
Contact & Investigator
Manoj Bhasin
PRINCIPAL INVESTIGATOR
Emory University
Frequently Asked Questions
Who can join the NCT07562451 clinical trial?
This trial is open to participants of all sexes, aged 8 Years or older, up to 18 Years, studying Sickle Cell Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07562451 currently recruiting?
Yes, NCT07562451 is actively recruiting participants. Contact the research team at manoj.bhasin@emory.edu for enrollment information.
Where is the NCT07562451 trial being conducted?
This trial is being conducted at Atlanta, United States.
Who is sponsoring the NCT07562451 clinical trial?
NCT07562451 is sponsored by Emory University. The principal investigator is Manoj Bhasin at Emory University. The trial plans to enroll 25 participants.
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