NCT06825936 Asian-Mediterranean Diet and Women's Health
| NCT ID | NCT06825936 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Global Centre for Asian Women's Health |
| Condition | Cardiometabolic Risk Factors |
| Study Type | INTERVENTIONAL |
| Enrollment | 300 participants |
| Start Date | 2025-02-10 |
| Primary Completion | 2026-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 300 participants in total. It began in 2025-02-10 with a primary completion date of 2026-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Given the escalating high burdens of overeight and obesity, and related commobidies in Asia, Asian women with overweight/obesity is an important group for targeted intervention in promoting health and wellbeing. A study focused on Asian women at reproductive or early post-menopausal age can inform effective strategies for promoting healthy diet and lifetyle and for optimizing health not only among these women but also for their children and partners. The Mediterranean diet has beneficial effects on cardiometabolic and reproductive health. So far, evidence on the Mediterranean diet and its health benefits mostly come from Western populations. Studies evaluating health effects of Mediterranean diet in Asian population are scant. This study aims to investigate the beneficial effects of a healthy, Mediterranean-inspired localized diet (i.e., Asian-Mediterranean diet) on women's health, such as cardiometabolic health with potential mechanisms through modulating gut and brain health.
Eligibility Criteria
Inclusion Criteria: Subjects must meet all of the inclusion criteria for participation: 1. Females aged 21-50 years 2. Chinese ethnicity 3. Singapore citizens, permanent residents, or long-term pass holders 4. Is able to complete questionnaires in English 5. BMI ≥ 23.0 kg/m2 but \< 37.5 kg/m2 6. Not planning to conceive in the next 12 months from enrolment (you will be asked to withdraw once you conceive during the study period) 7. Not planning to leave Singapore for more than 2 consecutive calendar weeks (10 working days) in the next six months from enrolment 8. Not currently pregnant or breastfeeding 9. Not currently smoking 10. Without history of major chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, chronic kidney disease), major infectious diseases (e.g. hepatitis B, HIV), severe gastrointestinal disorders (e.g. colitis or inflammation of the bowel, celiac disease, chronic gastritis) and major medical procedures/surgeries related to these conditions 11. Without major mental health condition 12. Without known food allergies, especially to nuts and seafood. 13. Not on any special diets or having dietary restrictions (e.g. vegetarians, vegans, ketogenic, Kosher diet) 14. Not currently and will not be enrolled in another interventional study or studies that may affect weight, cardiometabolic health, gut, or brain health in the next six months from enrolment Exclusion Criteria: Subjects not meeting any of the above inclusion criteria will be excluded from participation. Additional Exclusion Criteria for MRI procedure only: i. Shoulder width ≥60cm ii. Has any medical implants or foreign bodies, particularly related to heart, brain, or eye implants, including but not limited to pacemakers, artificial heart valves, implantable cardioverter defibrillators, ventricular assist devices, brain stimulation devices, intrauterine devices, and breast biopsies (if any implant or tissue marker has been placed) iii. History of head injury or trauma with loss of consciousness iv. Metallic dental braces or dental implants v. Having claustrophobia vi. Drinks more than 30 units of alcohol per week (1 unit = 25mL 40% spirit, 1 can of beer = 2 units, 1 standard glass of wine = 2 units)
Contact & Investigator
Cuilin Zhang, MD, MPH, PhD
PRINCIPAL INVESTIGATOR
Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore
Frequently Asked Questions
Who can join the NCT06825936 clinical trial?
This trial is open to female participants only, aged 21 Years or older, up to 50 Years, studying Cardiometabolic Risk Factors. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06825936 currently recruiting?
Yes, NCT06825936 is actively recruiting participants. Contact the research team at jiaxiyang@nus.edu.sg for enrollment information.
Where is the NCT06825936 trial being conducted?
This trial is being conducted at Singapore, Singapore.
Who is sponsoring the NCT06825936 clinical trial?
NCT06825936 is sponsored by Global Centre for Asian Women's Health. The principal investigator is Cuilin Zhang, MD, MPH, PhD at Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore. The trial plans to enroll 300 participants.