NCT07929922 Arthrocentesis vs Observation Study for Acute ACL Tears
| NCT ID | NCT07929922 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ohio State University |
| Condition | Anterior Cruciate Ligament (ACL) Tear |
| Study Type | INTERVENTIONAL |
| Enrollment | 54 participants |
| Start Date | 2026-08-01 |
| Primary Completion | 2028-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 54 participants in total. It began in 2026-08-01 with a primary completion date of 2028-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The ASPIRATE trial is a randomized controlled trial evaluating the effects of pre- and post-operative knee joint aspiration in patients with an ACL injury. The study aims to determine if removing knee joint fluid can mitigate the increasing inflammation after surgery, reduce quadriceps atrophy, improve short-term pain, enhance functional recovery, and lower long-term rates of post-traumatic knee osteoarthritis.
Eligibility Criteria
Inclusion Criteria: 1. Age 15 -40 2. Time from injury to aspiration ≤30 days 3. Patient with a confirmed ACL tear and have elected to have an ACL reconstruction using a quadriceps tendon (QT) or bone-patellar tendon-bone (BPTB) autograft tendon Exclusion Criteria: 1. Fear of needles or rejection of arthrocentesis 2. Previous knee or ACL surgery on the affected knee 3. Previous cortisone injection in the affected knee within the previous 3 months 4. Concomitant procedures that involve repair or reconstruction of the medial collateral ligament (MCL), posterolateral corner (PLC) or posterior cruciate ligament reconstruction (PCL) 5. Osteoarthritis Kellgren-Lawrence grade ≥3. 6. Cartilage procedures beyond microfracture or chondroplasty 7. Planned osteotomies or meniscus allograft transplantation (MAT) 8. Muscular, vascular or neurological diseases that influence rehabilitation or surgery 9. Current use of prednisone or cytostatic medication 10. Obesity with a BMI ≥45 11. Daily smoking 12. History of illicit drug or alcohol abuse 13. History of prior infection in knee 14. History of chemotherapy treatment 15. History of sickle cell disease 16. Pregnancy during injury or surgery 17. No mastery of the English language
Contact & Investigator
Jelle van der List, MD, PhD
STUDY DIRECTOR
Ohio State University
Frequently Asked Questions
Who can join the NCT07929922 clinical trial?
This trial is open to participants of all sexes, aged 15 Years or older, up to 40 Years, studying Anterior Cruciate Ligament (ACL) Tear. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07929922 currently recruiting?
Yes, NCT07929922 is actively recruiting participants. Contact the research team at michael.keller@osumc.edu for enrollment information.
Where is the NCT07929922 trial being conducted?
This trial is being conducted at Columbus, United States, Dublin, United States.
Who is sponsoring the NCT07929922 clinical trial?
NCT07929922 is sponsored by Ohio State University. The principal investigator is Jelle van der List, MD, PhD at Ohio State University. The trial plans to enroll 54 participants.