NCT07462000 Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
| NCT ID | NCT07462000 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Military Institute od Medicine National Research Institute |
| Condition | Primary Open-Angle Glaucoma (POAG) |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2026-01-21 |
| Primary Completion | 2027-01-21 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years. * Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation). * Ability to provide written informed consent. * For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure. * For control arm: cataract without glaucoma and without other significant ocular pathology. Exclusion Criteria: * Age \< 18 years. * Pregnancy or breastfeeding. * Advanced visual impairment in the study eye (visual aquity worse than counting fingers). * Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma). * History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery. * Active or previous uveitis. * Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm). * Inab