NCT07384403 Application of Topical Oxygen Therapy Around Customized Healing Collar
| NCT ID | NCT07384403 |
| Status | Recruiting |
| Phase | Phase 4 |
| Sponsor | Cairo University |
| Condition | Soft Tissue |
| Study Type | INTERVENTIONAL |
| Enrollment | 6 participants |
| Start Date | 2026-01-01 |
| Primary Completion | 2026-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 4 studies follow an already-approved treatment in real-world conditions to monitor long-term safety and effectiveness.
This trial targets 6 participants in total. It began in 2026-01-01 with a primary completion date of 2026-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The preservation and enhancement of peri-implant soft tissues are essential for the long-term success and esthetic integration of dental implants. Customized healing abutments have been introduced to support individualized soft tissue shaping; however, optimizing soft tissue healing around implants remains a clinical challenge. Oxygen plays a critical role in wound healing by promoting angiogenesis, fibroblast proliferation, and collagen synthesis. Topical oxygen therapy has shown promise in accelerating tissue regeneration, yet its application in oral implantology, particularly in conjunction with customized healing abutments, has not been adequately studied. This study aims to provide clinical evidence regarding the effectiveness of topical oxygen therapy in improving linear and volumetric soft tissue changes around dental implants. The findings may guide clinicians in refining soft tissue management protocols and contribute to establishing evidence-based practices in implant dentistry.
Eligibility Criteria
Inclusion Criteria: * Adults aged 21 years and above. * Indicated for customized healing collar placement after second-stage surgery. * Good general health. * Able and willing to provide written informed consent. * Committed to follow-up visits. Exclusion Criteria: * Individuals below 21 years old. * Systemic diseases affecting healing. * Smokers/tobacco users. * Pregnant/lactating women. * Medications affecting soft tissue healing. * Chemotherapy/radiotherapy patients.
Contact & Investigator
Mulhem ahmed
PRINCIPAL INVESTIGATOR
Cairo University
Frequently Asked Questions
Who can join the NCT07384403 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, studying Soft Tissue. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07384403 trial and what does that mean for participants?
Phase 4 studies are conducted after a treatment has been approved. They monitor long-term safety and real-world effectiveness in a broader patient population.
Is NCT07384403 currently recruiting?
Yes, NCT07384403 is actively recruiting participants. Contact the research team at mulhem.ahmad@dentistry.cu.edu.eg for enrollment information.
Where is the NCT07384403 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07384403 clinical trial?
NCT07384403 is sponsored by Cairo University. The principal investigator is Mulhem ahmed at Cairo University. The trial plans to enroll 6 participants.