Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease
Trial Parameters
Brief Summary
Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease (CKD)? Aims and objectives: 1. To establish a multiparametric renal MRI protocol in CKD cohorts. 2. To use multiparametric MRI to characterise people with and without CKD progression. 3. To compare multiparametric renal MRI with 'gold-standard' renal biopsy to determine pathological processes of CKD progression that are detectable by MRI.
Eligibility Criteria
Inclusion Criteria * Age 18-75 years * CKD category G3-4 or CKD category G1-2 with overt albuminuria (urine ACR\>30mg/mmol) * Capable of giving informed consent Exclusion Criteria * Autosomal dominant polycystic kidney disease (ADPKD) * Glomerulonephritis (GN) actively receiving immunosuppression, or within the preceding 90 days. * Multiple myeloma (MM) * Acute Kidney Injury (AKI) within the preceding 90 days * Solid organ transplant * Known single kidney * Contraindications to MRI (e.g. permanent pacemaker, metallic foreign bodies, claustrophobia etc.)